Conducta actual frente la hemorragia digestiva alta: desde el diagnóstico al tratamiento / Current behavior against Upper Digestive Hemorrhage: from diagnosis to treatment

Resumen La hemorragia digestiva alta (HDA) es una emergencia médico-quirúrgica común que debe ser tratada precozmente por su alta morbimortalidad. Corresponde a sangrado del esófago, estómago o del duodeno proximal, y se divide en etiología no variceal y variceal. Dentro de las no variceales destaca la úlcera péptica como la más frecuente, siendo esta producida por un desbalance entre factores protectores y agresivos. Por otro lado, en las hemorragias variceales destacan las várices gastroduodenales, las cuales son consecuencia del aumento de la presión portal. La incidencia de la HDA a nivel mundial varía entre 37 a 172 casos por cada 100.000 habitantes por año y la mortalidad entre un 5 y un 14% según diferentes estudios. Lamentablemente, no existen cifras nacionales fidedignas de incidencia y prevalencia. El médico debe conocer bien la presentación clínica y la fisiopatología para ser asertivo en la sospecha, diagnóstico y manejo de esta patología. En cuanto al tratamiento, el enfrentamiento se divide en el manejo de urgencias y luego endoscópico, puesto que la resucitación temprana intensiva puede reducir la morbimortalidad en pacientes con HDA. A continuación se hará una revisión actualizada enfocada en los aspectos más relevantes del manejo de esta patología. Se obtuvieron los datos de Pubmed y Scielo, específicamente la búsqueda de artículos originales y de revisiones sistemáticas con las palabras "hemorragia digestiva alta", "úlcera péptica", "várices esofágicas" y otras relacionadas. Los criterios usados fueron artículos preferentemente menores a 5 años de publicación en revistas científicas de alto índice de impacto.

Upper gastrointestinal bleeding (UHD) is a common medical-surgical emergency that must be treated early due to its high morbidity and mortality. It corresponds to bleeding from the esophagus, stomach, or proximal duodenum, and is divided into non-variceal and variceal etiology. Among the non-variceal, the peptic ulcer stands out as the most frequent, being this produced by an imbalance between protective and aggressive factors. On the other hand, in variceal hemorrhages gastroduodenal varices stand out, are a consequence of increased portal pressure. The incidence of HDA worldwide varies between 37 to 172 cases per 100,000 inhabitants per year and mortality between 5 to 14% according to different studies. Unfortunately, there are no reliable national statistics of incidence and prevalence. The physician must have a good understanding of the clinical presentation and pathophysiology to be assertive in the suspicion, diagnosis, and management of this pathology. Regarding treatment, the confrontation is divided into emergency management and then endoscopic, because early intensive resuscitation can reduce morbidity and mortality in patients with UHD. This is an updated review which will be focused on the most relevant aspects of the management of this pathology. Data were obtained from Pubmed and Scielo, specifically searching for original articles and systematic reviews with the words "upper gastrointestinal bleeding", "peptic ulcer", "esophageal varices" and other related words. The criteria used were articles preferably less than 5 years old in scientific journals with a high impact index.

Endoscopic management of foreign bodies in the upper gastrointestinal tract

Background: Foreign body ingestion and food bolus impaction is a common clinical scenario and can present as an endoscopic emergency. Though majority of them pass spontaneously 10-20% require endoscopic intervention. Flexible endoscopy is recommended as therapeutic measure with minimal complications. The aim of our study is to present 5 years’ experience in dealing with foreign bodies in the upper gastrointestinal tract.Methods: Cases of foreign body ingestion admitted to department of general surgery from March 2015 to March 2020 were evaluated. The patients were reviewed with details on age, sex, type of FB, its location in gastrointestinal tract, treatment and outcome.Results: A total of 55 cases were studied. Age range was 1-85 years. Males were predominant 61.81%. Coins were found most commonly 63.6%. Esophagus was the commonest site of FB lodgement 70.9%. Upper esophagus being the most common 36.36%. Upper gastrointestinal flexible endoscopy was useful in retrieving FB in all the 55 cases. There were no complications throughout the study period.Conclusions: Flexible endoscopy should be used as definitive treatment and endoscopic treatment is safe and effective.

Endoscopic Management with a Novel Over-The-Scope Padlock Clip System

BACKGROUND/AIMS: The Padlock clip is a recently introduced over-the-scope clip (OTSC) that requires the use of an alternate technique and has a different design from previous OTSCs. However, data regarding its clinical use are limited. The aim of this study is to present our clinical experience using this novel Padlock clip system.METHODS: Between September 2018 and June 2019, 7 consecutive patients underwent Padlock clip application at our center by an experienced endoscopist. A Padlock clip was used for achieving hemostasis in 4 patients presenting with gastrointestinal (GI) bleeding, as well as for endoscopic full-thickness resection in the remaining 3 patients.RESULTS: All 7 patients achieved technical as well as clinical success, with absence of complications or rebleeding, during a follow-up of a minimum of 3 weeks. All patients were hospitalized post procedure for a minimum of 48 hours, and an absence of adverse events was noted in our patient population throughout the procedure and post-procedure period. Antiplatelet therapy was reinstated shortly after the application of the Padlock clip, with no GI bleeding observed.CONCLUSIONS: The Padlock clip is a novel OTSC, with benefits that include safe, simple, and rapid deployment. Antiplatelet therapy may be reinstated for patients, when necessary, shortly after applying the Padlock clip due to full-thickness closure of the tissue.

Laryngo Tracheal Stenosis : Management And Its Outcomes

Introduction: Laryngotracheal stenosis (LTS) implies a partial or complete narrowing of the larynx and/or trachea. Surgical management of it is technically challenging due to complex anatomy and delicate nature of airway structures. Ourstudy aims to study clinical profile, management, and surgical outcome of LTS. Materials and Methods: All patients with LTS treated between 2015 and 2018 were included in in our study.They underwent endoscopic assessment followed by definitive management which included endoscopic and external surgical techniques. The success of treatment was defined by decannulation Subjective assessment of voice quality.Results: A total of 30 patients with benign LTS were treated. Prolonged intubation was the single largest cause (56%). subglottic stenosis formed the largest group (74%) followed by Tracheal stenosis (14%).patiens were devided in four group depending upon surgical procedure they underwent:GROUP–I,endoscopic laser excision and dilatation(12cases),GROUP–II laryngo tracheoplasty and t–tube insertion(10 cases),GRUP–III tracheal stent insertion(3 cases),GROUPIV–Rection and anstomosis.Rate of decannalation following this surgical procedure in GROUP–I,GROUP–II,GROUP–III and GROUP–IV were 58%,60%,33% and80%.A total of 19 patients (63%) have been successfully decannulated. Conclusions: The use of appropriate size, low pressure cuffed tubes, and early tracheostomy will help in preventing LTS. The precise assessment of laryngotracheal complex is most useful in planning of management. Choice of treatment depends on location, severity, and length of stenosis, as well as on patient comorbidities an dhistory of previous interventions. Goal of our treatment modality is to achieve a patent airway and acceptable voice quality.

¿Son útiles las prótesis metálicas autoexpandibles en el control de la hemorragia digestiva varicosa refractaria? / Are self-expanding metal prostheses useful for controlling refractory variceal digestive hemorrhaging?

Resumen El sangrado varicoso es una urgencia médica con altas tasas de morbimortalidad. De los pacientes que llegan para recibir manejo hospitalario, hasta un 10% no responden a medidas hemostáticas convencionales, por lo que se ha planteado el uso de prótesis metálicas autoexpandibles para el manejo con resultados prometedores de dichos pacientes. En el presente documento se discute la literatura mundial disponible acerca de la experiencia en el uso de dichos dispositivos; la eficacia en el control agudo; el pronóstico a largo plazo; el tipo de prótesis utilizadas y las alternativas, complicaciones y retos del manejo de pacientes con esta técnica, que puede considerarse emergente en nuestro medio.

Abstract Variceal bleeding is a medical emergency which has high rates of morbidity and mortality. Up to 10% of these patients treated in hospitals do not respond to conventional hemostatic measures. For this reason, the use of self-expanding metal stents (SEMS) has been proposed for management of these patients. It has had promising results. This paper discusses the literature available internationally about experience with the use of SEMS, their efficacy for acute control, long-term patient prognoses, types of stents, alternatives, complications, and challenges for the use of SEMS for patient management that should be considered in our environment.

Manejo endoscópico de quiste de duplicación esofágico: descripción de un caso / A case of endoscopic management of an esophageal duplication cyst

Resumen Los quistes de duplicación esofágica son una anomalía congénita poco frecuente. La mayoría de los casos son asintomáticos y su diagnóstico frecuentemente es un hallazgo incidental. La posibilidad de que se desarrollen complicaciones (hemorragia, infección, entre otras) y el temor a la posibilidad de transformación maligna hacen que el tratamiento de estas lesiones haya sido considerado quirúrgico en el pasado. Sin embargo, la extremadamente baja tasa de malignización y la posibilidad de un desenlace inadecuado asociado con la cirugía hacen considerar otras alternativas, teniendo en cuenta la relación riesgo-beneficio del procedimiento quirúrgico. Se reporta el caso de una paciente de 56 años con diagnóstico endosonográfico de quiste de duplicación esofágica, que fue sometida a marsupialización endoscópica del quiste con una resolución completa de sus síntomas, sin complicaciones y con una reintegración inmediata a la vida diaria. La endosonografía (EUS) ha sido ampliamente utilizada como una herramienta para la evaluación y el diagnóstico de los quistes de duplicación. Es el método diagnóstico de elección para investigar esta patología ya que puede distinguir entre lesiones sólidas y quísticas. La cuestión de si se debe realizar o no la aspiración con aspiración con aguja fina guiada por EUS (FNA) en una lesión sospechosa, en el caso de un quiste de duplicación, es controvertida ya que estas lesiones pueden infectarse con consecuencias significativas, aunque frecuentemente se requiere que la punción obtenga un diagnóstico definitivo que descarte lesiones ominosas.

Abstract Esophageal duplication cysts are rare congenital anomalies. Most cases are asymptomatic and their diagnoses are often incidental findings. In the past, surgery was considered to be the treatment for these lesions because of the possibility of complications such as hemorrhaging and infections as well as the fear of malignant transformation. However, the extremely low rate of malignancy and the possibility of an inadequate outcomes of surgery have made it necessary to consider other alternatives that taking both risks and benefits of the surgical procedure into account. We report the case of a 56-year-old patient with an endosonographic diagnosis of an esophageal duplication cyst who underwent endoscopic marsupialization of the cyst followed by complete resolution of symptoms, without complications, and with immediate reintegration into daily life. Endosonography (EUS) has been widely used as a tool for evaluation and diagnosis of duplication cysts. It is the diagnostic method of choice for investigating this pathology since it can distinguish between solid and cystic lesions. The question of whether or not to perform EUS guided fine needle aspiration (FNA) of a lesion suspected of being a duplication cyst is controversial since these lesions can be infected with significant consequences. Nevertheless, EUS-FNA is often required to make a definitive diagnosis that rules out ominous lesions.

Retrospective analysis of emergent endoscopic management of foreign bodies in the upper gastrointestinal tract / 中国内镜杂志

Objective To present novel measures in endoscopic removal of foreign bodies in the upper gastrointestinal tract. Methods The clinical trial performed a retrospective analysis of emergency endoscopic management of 251 cases of foreign bodies in the upper gastrointestinal tract from January 2013 to November 2016. The patients underwent gastric endoscopic examinations under local pharyngeal anesthesia or general intravenous anesthesia. Flexible endoscopes and retrieval accessories such as rat-tooth and alligator forceps, polyp snares, polyp graspers, dormia basket, lithotripter or grasping forceps or rubber gloves were used for the endoscopic procedures. We reviewed of patients' general data (age, sex, type of foreign body), type of anaesthesia, foreign bodies' locations, type of accessory, complications, success rate. Results A total of 251 foreign bodies were definitely diagnosed through endoscopy, 248 foreign bodies were successfully removed with compatible devices according to the foreign bodies' location, nature, and size, and 3 cases failed. At the same time, 192 cases had little mucosal laceration and bleeding, and 45 cases were found to have underlying diseases. 1cases had esophageal surgery and 1cases had laryngeal surgery. 1 cases refuse to remove the foreign body because no symptoms and therapheutic risks. Conclusion Emergency endoscopic management is the foremost option for foreign bodies in the upper gastrointestinal tract, for its obvious advantages in safety, efficiency, low cost, and minimal invasion. Endoscopic intervention can also diagnose early underlying digestive diseases. Innovative measures can increase the successful rate of removing foreign bodies with gastric endoscopy.

Endoscopic Endonasal Repair of Congenital Basal Encephalocele: Report of 3 Cases / 대한이비인후과학회지

Encephalocele is a malformation characterized by protrusions of the brain and meninges through openings in the cranial bones. They are managed surgically and approached in various ways, mainly on the basis of its location. Basal encephaloceles have been traditionally approached intracranially via bicoronal approach in the pediatric population. We report three cases of congenital basal encephaloceles treated by endoscopic endonasal approach in our institution. In 2 patients, the skull base defect was successfully corrected whereas in one case, recurrence was observed. No major complications were encountered. Although the endoscopic endonasal repair approach of basal encephaloceles in the pediatric population is associated with potential technical difficulties, it is a viable and minimally invasive alternative to the traditional craniotomy.

The Endoscopic Management of Common Bile Duct Stones / 대한내과학회지

Gallbladder stone, or gallstone, is an endemic condition that affects up to 20% of the general population. Of patients with gallstones, 11-21% also have concomitant common bile duct (CBD) stones. Moreover, in East Asia-including Korea, Taiwan, and Japan-the prevalence of primary CBD stones without gallbladder stones is higher than that in Western countries. CBD stones may be associated with various symptoms and conditions. Therefore, CBD stones must be managed for the prevention of potentially life-threatening complications, such as ascending cholangitis, liver abscess, and acute pancreatitis. During the past 40 years, endoscopic retrograde cholangiopancreatography has become a widely available and routine procedure for the management of CBD stones. Other interventions include intraoperative bile duct exploration and percutaneous transhepatic stone removal. As a consequence, clinicians are now faced with a number of potentially valid options for managing patients with suspected CBD stones.

Reporte de caso y revisión de la literatura: manejo endoscópico de fístula traqueoesofágica recurrente con electrocauterio y pegante tisular / Endoscopic management of recurrent tracheoesophageal fistula with fibringlue and electrocautery

Las fístulas traqueoesofágicas recurrentes (FTER) continúan siendo un reto terapéutico debido a las altas tasas de morbilidad y mortalidad asociadas con su manejo quirúrgico abierto y su recurrencia frecuente. Las técnicas endoscópicas aportan un abordaje alternativo con el potencial de mejorar los resultados y desenlaces quirúrgicos. Se presenta un caso de cierre o reparo endoscópico de FTER mediante el uso de broncoscopia y esofagoscopia, así como una combinación entre técnica con electrocauterio y pegante tisular. Se considera que esta técnica puede representar una alternativa válida para el manejo de esta patología. Igualmente, se señala la importancia de considerar la fístula traqueoesofágica un diagnóstico diferencial en pacientes pediátricos con infecciones respiratorias recurrentes...

Recurrent Tracheoesophageal Fistulas (RTEF) remainsa therapeutic challenge, cause of the highrates of morbidity and mortality associated withopen surgical closure and their frequent recurrence.Endoscopic techniques provide an alternativeapproach with the potential for improved surgicaloutcomes. We present a case of successful repairof recurrent tracheoesophageal fistula using bronchoscopyand esophagoscopy, as well as a combinedtechnique with electrocautery and fibrin glue.We believe this might represent a valid alternativefor the management of RTEF. We also want topoint out the importance of considering primaryor recurrent tracheoesophageal fistula in pediatricpatients with recurrent respiratory tract infections...

Endoscopic treatment for foreign body impaction in esophagus / 中华消化内镜杂志

ObjectiveTo assess the efficacy and safety of endoscopic treatment for foreign body impaction in the esophagus.MethodsDemographic and endoscopic data of a total of 78 patients with esophagus foreign body impactions were retrospectively studied,which included foreign body types,number,location and duration of impaction,associated esophageal diseases,endoscopic procedures and complications.The factors which influenced the complications and procedure time were also statistically analyzed.Results Impaction (80.7％ ) and perforation (66.7％ ) most frequently occurred in the upper esophagus.Duration of foreign body impaction exceeded 24 hours in 11 patients ( 14.1％ ),which was less than 24 hours in 67 others (85.9％).All of the foreign bodies were successfully removed (2 cases of perforation were transferred to other department for further treatment),and there was no mortality related to endoscopic management occurred.The common complications included mucosal injury,bleeding,and perforation.Shape of the foreign bodies,duration of impaction and status of perforation were the main influential factors on procedure time and complications (P ＜ 0.05).ConclusionThe endoscopic management for esophageal foreign body impaction is safe and effective. It is the first choice for those whose esophagus is perforated with foreign bodies for less than 24 hours and with no abscesses out of esophageal tract.

Endoscopic Diagnosis and Treatment of Benign Biliary Strictures

Benign biliary strictures constitute about 25% of all biliary strictures. Benign biliary strictures are a heterogenous group of lesions with variousvariable pathogenesis. The majority of benign biliary strictures occur as a result of bile duct injury during surgery or as a consequence of bile duct repair after accidental injury, performing , choledochotomy, or performing duct-to-duct anastomosis after liver transplantation. However, bile duct strictures are also typical of other diseases, such as chronic pancreatitis, primary sclerosing cholangitis, and other uncommon cholangiopathies. The aim of treatment is to relieve the symptoms of biliary obstruction or cholangitis, and to prevent of secondary biliary cirrhosis. The Management of benign biliary stricture remains a challenge for both the surgeons and the therapeutic endoscopists. Surgery is, though traditionally considered as the mainstay of treatment, but this is associated with significant morbidity and variousvariable long-term outcomes. Endoscopic management, i.e., stricture dilatation and stent placement, is more appealing because it is less invasive, better tolerated, and it may be safer than operative management in selected patients. Recently, benign biliary strictures are now being increasing treated with endoscopic techniques. The Outcome of endoscopic management depends on both the etiology and location of the stricture. The benign nature of the stricture should be first confirmed in order to ensure appropriate therapy. The Current data suggest that the long-term results with using multiple plastic stent are superior to those with using a single plastic stent. Removable covered metal stents are also a good alternative. The role of bio-absorbable self-expanding stents for treating benign biliay strictures needs to be evaluated further.

The present and the future of therapeutic endoscopy in the pancreatic disease / 대한내과학회지

No abstract available.

Overall Success and Factors Predicting Failure for Endoscopic Extrahepatic Biliary Stone Extraction / 대한내과학회지

OBJECTIVES: Developments in endoscopic technique and equipments have improved duct clearance rate in patients with extrahepatic bile duct(EHBD) stone. In this study, we reviewed our experience in extracting EHBD stones with standard and more advanced technique and equipments such as mechanical lithotripsy and extra corporeal shock wave lithotripsy. Aims of this study were to determine the overall success rate of endoscopic ex tracting for EHBD stone, to identify risk factors for failed duct clearance at initial and final therapeutic ERCP. METHODS: We retrospectively reviewed 214 consec utive patients who underwent Endoscopic Retrograde Cholangiopancreatography(ERCP) for EHBD stone over 45 months period. Factors evaluated for failed duct clearance included stone size, stone number, stone shape, concomitant stone of gallbladder and intrahepatic duct, presence of distal bile duct stricture, periampullary diverticula(PAD), Billroth-II gastrojejunostomy, and sepsis at admission. RESULTS: The overall success rate of endoscopic treatment for EHBD stone was 93.5% (200/214). The causes of failed duct clearance were failed endoscopic sphincterotomy in 5/214 (2.3%), technical failure of extracting stone in 5/214(2.3%), and aggravation of acute cholecystitis between therapeutic endoscopic sessions in 4/214(1.9%). Risk factors for failed duct clearance with endoscopic extraction of EHBD stone were size and shape of the stone, concomitant stone of gallbladder and intra hepatic duct, and stricture of distal common bile duct. The duct clearance rate with initial therapeutic ERCP was 56.5%(121/200). Risk factors for failed duct clearance with initial therapeutic ERCP were size, shape and number of stone, and sepsis at admission. The com plications of endoscopic treatment for EHBD stone were major bleeding in 5/200 (2.5%), pancreatitis in 18/200 (9.0%), but there was no perforation. CONCLUSION: Eventhough risk for failure of endo scopic treatment for EHBD stone were giant or piston shaped stone, concomitant stone of gallbladder and intra hepatic duct, and stricture of distal common bile duct, we conclude that endoscopic treatment for EHBD stone is safe and effective treatment modality, and choice of treatment.